Clare Scott Chialvo, Reed Lab postdoctoral fellow, collaborated with the Werner Lab at Michigan Technological University to write a review on toxin tolerance.
Drosophila, destroying angels, and deathcaps! Oh my! A review of mycotoxin tolerance in the genus Drosophila is available in Frontiers in Biology.
Figure 1 Four mechanisms that are hypothesized to contribute to the resistance to α-amanitin in the D. melanogaster Ama-KTT strain. α-Amanitin is shown as a red 8. Cuticular proteins block some of the α-amanitin from entering the cells (blockage). α-Amanitin that entered the cytoplasm is either sequestered in lipid particles, cleaved by peptidases, or detoxified by phase I and II detoxification enzymes, possibly followed by excretion. Figure adapted from Mitchell change to et al. (2014).
Kelsey and Brélahn just got back from Philadelphia, where they presented a poster entitled "Assessing the genetic- and sex-specific interactions of adult exercise and poor larval diet in Drosophila" at the 59th Annual Drosophila Research Conference.
Here's what Kelsey had to say about the trip: "While we took some time our first day to explore the beauty and history of such an iconic city in our country, most of our extended weekend was spent listening to the biggest and brightest minds in Drosophila biology share their research. I was blown away by some of the emerging technology and techniques introduced in the talks. They really stimulated a wealth of new ideas and directions in which we could expand the TreadWheel experiment to answer new and exciting questions. I was also able to meet other researchers in the field of fly exercise and metabolism for the first time. To say I was a little star struck when a couple of them came to visit us at our poster would be an understatement. Overall, this conference was such an edifying experience that helped introduce me to a wide variety of questions that fly research is currently answering and hopes to resolve soon. Thank you Laura for such a wonderful chance to meet and share ideas with various members and leaders of the fly community!"